9/5/2023 0 Comments Cascadea brazilBecause RT shares a sensitivity and specificity similar to other HCV serological methods, they do not need a laboratory structure and are a great approach to increasing HCV diagnosis. RTs are easy to perform, yield faster results, and are cheaper. In 2011, the US Food and Drug Administration approved the use of rapid tests (RTs) to detect HCV infection. Anti-HCV antibodies can be detected by immunological methods however, these methods are costly and require long procedure times. Hepatitis C is commonly diagnosed by serological tests. These studies confirmed Brazil as a country with low endemicity for hepatitis C. It is postulated that the HCV prevalence in Brazil increased with age and is higher in adults born between 19, with genotype 1 most prevalent of chronic infections. The first Brazilian nationwide hepatitis survey demonstrated an HCV seroprevalence of 1.38% in 19,503 individuals. Studies assessing HCV prevalence in Brazil are scarce, and the HCV seroprevalence is estimated between 0.69 to 1.89%. It comprises incorporating new, effective, affordable drugs guiding physicians in treating HCV patients, and promoting diagnostic campaigns in populations aged > 40 years, as recent studies have shown a higher prevalence of infection. Ī strategic plan has been outlined recently to address HCV infection in Brazil. Therefore, expanding the knowledge of HCV infection is essential to establish new HCV prevention and elimination programs in Brazil. ![]() Currently, the main challenge is improving the diagnosis of chronic hepatitis C and having patients commence treatment to prevent liver cirrhosis and HCC. To address this issue, it is crucial that the number of diagnoses and the access to treatment in most countries must be increased at least fivefold. with about 40% of liver cancers expected to be caused by HCV by 2030. Despite recent advances in hepatitis C treatment, the number of people with advanced liver disease and the number of liver disease-related deaths are predicted to increase in the coming years. In 2017, an estimated 71 million people (about 1% of the world population) had active hepatitis C virus (HCV) infection, according to the Global Hepatitis Report by the World Health Organization (WHO). Hepatitis C is also associated with several comorbidities, such as cardiovascular and metabolic disease. Research Ethics Committee of the Faculty of Health Sciences of the University of Brasília - UNB (CAAE number 778183.0030) and by the Ethics Committee of the Health Science Teaching and Research Foundation - FEPECS/SES/DF (CAAE number 778183.5553).Ĭhronic hepatitis C is a global public health problem, with a risk of progression to cirrhosis and hepatocellular carcinoma (HCC). This study opens new avenues for eliminating HCV infection and suggests that partnerships with clinical laboratories to conduct anti-HCV tests are a useful strategy to improve HCV diagnosis. The prevalence of HCV-positive patients was low in Brasilia, and the gaps in the cascade of care for these patients were significantly below the targets of HCV infection elimination. By the end of the study, 16 patients were still awaiting to receive medication. Additionally, of the 161 patients, 55 (34.1%) were referred for treatment, but only 39 (24.2%) complied, with 36 (22.4%) showing sustained virological response. Among 65 patients (94.2%) who underwent transient elastography, 30 (46.2%) presented with advanced fibrosis. Genotype 1 (75%) was the most prevalent genotype. Among 161 patients with positive anti-HCV serology, 124 (77%) were contacted, 109 (67.7%) were tested for HCV RNA viral load, and 69 (42.8%) had positive results. The prevalence of positive serology was 0.27%. HCV-positive patients were contacted and scheduled to undergo the HCV RNA viral test, genotyping, and transient elastography. This cross-sectional study analyzed 57,697 rapid screening tests for hepatitis C in individuals aged > 40 years between June 2018 and June 2019. ![]() This study aimed to estimate the prevalence of positive anti-HCV serology in Brasilia, Brazil, and evaluate the efficiency of the cascade of care for HCV-positive individuals. Identifying patients with hepatitis C virus (HCV) infection and enhancing the cascade of care are essential for eliminating HCV infection.
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